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Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy.

Abstract Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Recent studies have demonstrated that HPV-transformed cells actively promote chronic stromal inflammation and conspire with cells in the local microenvironment to promote carcinogenesis. This review highlights the complex interplay between HPV-infected cells and the local immune microenvironment during oncogenic HPV infection, persistence, and malignant progression, and discusses new prospects for diagnosis and immunotherapy of HPV-associated cancers.
PMID
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Authors

Mayor MeshTerms
Keywords

IL-6

JAK-STAT3

cervical cancer

chronic inflammation

epidermodysplasia verruciformis

human papillomavirus

immune evasion

immunoscore

immunotherapy

skin cancer

Journal Title viruses
Publication Year Start




PMID- 28895886
OWN - NLM
STAT- In-Process
DA  - 20170912
LR  - 20170912
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Sep 12
TI  - Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy.
LID - E254 [pii]
LID - 10.3390/v9090254 [doi]
AB  - Human papillomavirus (HPV) infection is a causative factor for various cancers of
      the anogenital region and oropharynx, and is supposed to play an important
      cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors
      viral persistence. However, there is evidence that the mere presence of oncogenic
      HPV is not sufficient for malignant progression and that additional
      tumor-promoting steps are required. Recent studies have demonstrated that
      HPV-transformed cells actively promote chronic stromal inflammation and conspire 
      with cells in the local microenvironment to promote carcinogenesis. This review
      highlights the complex interplay between HPV-infected cells and the local immune 
      microenvironment during oncogenic HPV infection, persistence, and malignant
      progression, and discusses new prospects for diagnosis and immunotherapy of
      HPV-associated cancers.
FAU - Smola, Sigrun
AU  - Smola S
AD  - Institute of Virology, Saarland University Medical Center, 66421 Homburg/Saar,
      Germany. [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170912
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
OTO - NOTNLM
OT  - IL-6
OT  - JAK-STAT3
OT  - cervical cancer
OT  - chronic inflammation
OT  - epidermodysplasia verruciformis
OT  - human papillomavirus
OT  - immune evasion
OT  - immunoscore
OT  - immunotherapy
OT  - skin cancer
COI - The author declares no conflict of interest.
EDAT- 2017/09/13 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/09/13 06:00
PHST- 2017/08/25 [received]
PHST- 2017/09/07 [revised]
PHST- 2017/09/08 [accepted]
AID - v9090254 [pii]
AID - 10.3390/v9090254 [doi]
PST - epublish
SO  - Viruses. 2017 Sep 12;9(9). pii: E254. doi: 10.3390/v9090254.