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Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review.

Abstract Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease. In particular, CRS with eosinophilic features and/or nasal polyps (NPs) is often recalcitrant to current treatment; thus, appropriate animal models are mandatory to elucidate the pathogenesis of CRS and develop novel and efficient treatment modalities. The author reviewed the recently proposed animal models in CRS and discussed the pathophysiologic insights gained. Data Sources: Articles in the English language referenced in MEDLINE/PubMed from the year 2006 onward (for last 10 years). Review Methods: Review of the literature regarding animal models and related pathologic insights in CRS.
PMID
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Authors

Mayor MeshTerms
Keywords

Chronic rhinosinusitis

animal model

nasal polyps

Journal Title laryngoscope investigative otolaryngology
Publication Year Start




PMID- 28894808
OWN - NLM
STAT- PubMed-not-MEDLINE
DA  - 20170912
LR  - 20170914
IS  - 0023-852X (Print)
IS  - 2378-8038 (Linking)
VI  - 1
IP  - 5
DP  - 2016 Oct
TI  - Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review.
PG  - 116-123
LID - 10.1002/lio2.29 [doi]
AB  - OBJECTIVE: Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease.
      In particular, CRS with eosinophilic features and/or nasal polyps (NPs) is often 
      recalcitrant to current treatment; thus, appropriate animal models are mandatory 
      to elucidate the pathogenesis of CRS and develop novel and efficient treatment
      modalities. The author reviewed the recently proposed animal models in CRS and
      discussed the pathophysiologic insights gained. Data Sources: Articles in the
      English language referenced in MEDLINE/PubMed from the year 2006 onward (for last
      10 years). Review Methods: Review of the literature regarding animal models and
      related pathologic insights in CRS. RESULTS: Mouse, rabbit, and sheep models of
      CRS have been used for studying the pathogenesis of CRS. Most of researchers
      adopted animal models of CRS to prove any molecular mechanisms or therapeutic
      efficacy. In vitro or human findings and related hypothesis were evaluated in
      vivo using these models. In addition, novel therapeutic candidates for CRS with
      or without NP have been applied to animal models. CONCLUSION: Animal models have 
      elicited insights into the pathogenesis of CRS and also have been useful in
      testing new treatment modalities. Although there are still clear limitations in
      the animal studies, newly proposed or revised animal models would be helpful to
      understand the exact pathophysiology of CRS.
FAU - Shin, Hyun-Woo
AU  - Shin HW
AD  - Obstructive Upper Airway Research Laboratory, Department of
      PharmacologySeoulRepublic of Korea.
AD  - Ischemic/Hypoxic Disease Institute, Seoul National University College of
      Medicine;SeoulRepublic of Korea.
AD  - Cancer Research Institute, Seoul National UniversitySeoulRepublic of Korea.
AD  - the Department of Biomedical SciencesSeoul National University Graduate
      SchoolSeoulRepublic of Korea.
AD  - Department of Otorhinolaryngology-Head and Neck SurgerySeoul National University 
      HospitalSeoulRepublic of Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160802
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC5510259
OTO - NOTNLM
OT  - Chronic rhinosinusitis
OT  - animal model
OT  - nasal polyps
EDAT- 2017/09/13 06:00
MHDA- 2017/09/13 06:01
CRDT- 2017/09/13 06:00
PHST- 2016/07/01 [accepted]
AID - 10.1002/lio2.29 [doi]
AID - LIO229 [pii]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2016 Aug 2;1(5):116-123. doi: 10.1002/lio2.29.
      eCollection 2016 Oct.