OWN - NLM
DA - 20170912
LR - 20170914
IS - 0023-852X (Print)
IS - 2378-8038 (Linking)
VI - 1
IP - 5
DP - 2016 Oct
TI - Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review.
PG - 116-123
LID - 10.1002/lio2.29 [doi]
AB - OBJECTIVE: Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease.
In particular, CRS with eosinophilic features and/or nasal polyps (NPs) is often
recalcitrant to current treatment; thus, appropriate animal models are mandatory
to elucidate the pathogenesis of CRS and develop novel and efficient treatment
modalities. The author reviewed the recently proposed animal models in CRS and
discussed the pathophysiologic insights gained. Data Sources: Articles in the
English language referenced in MEDLINE/PubMed from the year 2006 onward (for last
10 years). Review Methods: Review of the literature regarding animal models and
related pathologic insights in CRS. RESULTS: Mouse, rabbit, and sheep models of
CRS have been used for studying the pathogenesis of CRS. Most of researchers
adopted animal models of CRS to prove any molecular mechanisms or therapeutic
efficacy. In vitro or human findings and related hypothesis were evaluated in
vivo using these models. In addition, novel therapeutic candidates for CRS with
or without NP have been applied to animal models. CONCLUSION: Animal models have
elicited insights into the pathogenesis of CRS and also have been useful in
testing new treatment modalities. Although there are still clear limitations in
the animal studies, newly proposed or revised animal models would be helpful to
understand the exact pathophysiology of CRS.
FAU - Shin, Hyun-Woo
AU - Shin HW
AD - Obstructive Upper Airway Research Laboratory, Department of
PharmacologySeoulRepublic of Korea.
AD - Ischemic/Hypoxic Disease Institute, Seoul National University College of
Medicine;SeoulRepublic of Korea.
AD - Cancer Research Institute, Seoul National UniversitySeoulRepublic of Korea.
AD - the Department of Biomedical SciencesSeoul National University Graduate
SchoolSeoulRepublic of Korea.
AD - Department of Otorhinolaryngology-Head and Neck SurgerySeoul National University
HospitalSeoulRepublic of Korea.
LA - eng
PT - Journal Article
PT - Review
DEP - 20160802
PL - United States
TA - Laryngoscope Investig Otolaryngol
JT - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC5510259
OTO - NOTNLM
OT - Chronic rhinosinusitis
OT - animal model
OT - nasal polyps
EDAT- 2017/09/13 06:00
MHDA- 2017/09/13 06:01
CRDT- 2017/09/13 06:00
PHST- 2016/07/01 [accepted]
AID - 10.1002/lio2.29 [doi]
AID - LIO229 [pii]
PST - epublish
SO - Laryngoscope Investig Otolaryngol. 2016 Aug 2;1(5):116-123. doi: 10.1002/lio2.29.
eCollection 2016 Oct.