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Epidermal Stem Cells in Skin Wound Healing.

Abstract Significance: Skin serves as a protective barrier for mammals. Epidermal stem cells are responsible for maintaining skin homeostasis. When cutaneous injuries occur, skin homeostasis and integrity are damaged, leading to dire consequences such as acute, chronic, or infected wounds. Skin wound healing is an intrinsic self-saving chain reaction, which is crucial to facilitating the replacement of damaged or lost tissue. Recent Advances: An immense amount of research has uncovered the underlying mechanisms behind the complex and highly regulated wound healing process. In this review, we will dissect the biological process of adult skin wound healing and emphasize the importance of epidermal stem cells during the wound healing. Critical Issues: We will comprehensively discuss the current clinical practices used on patients with cutaneous wounds, including both traditional skin grafting procedures and advanced grafting techniques with cultured skin stem cells. The majority of these leading techniques still retain some deficiencies during clinical use. Moreover, the regeneration of skin appendages after severe injuries remains a challenge in treatment. Future Directions: Understanding epidermal stem cells and their essential functions during skin wound healing are fundamental components behind the development of clinical treatment on patients with cutaneous wounds. It is important to improve the current standard of care and to develop novel techniques improving patient outcomes and long-term rehabilitation, which should be the goals of future endeavors in the field of skin wound healing.
PMID
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Authors

Mayor MeshTerms
Keywords

epidermal stem cells

skin

tissue regeneration

wound repair

Journal Title advances in wound care
Publication Year Start




PMID- 28894637
OWN - NLM
STAT- PubMed-not-MEDLINE
DA  - 20170912
LR  - 20170914
IS  - 2162-1918 (Print)
IS  - 2162-1918 (Linking)
VI  - 6
IP  - 9
DP  - 2017 Sep 01
TI  - Epidermal Stem Cells in Skin Wound Healing.
PG  - 297-307
LID - 10.1089/wound.2017.0728 [doi]
AB  - Significance: Skin serves as a protective barrier for mammals. Epidermal stem
      cells are responsible for maintaining skin homeostasis. When cutaneous injuries
      occur, skin homeostasis and integrity are damaged, leading to dire consequences
      such as acute, chronic, or infected wounds. Skin wound healing is an intrinsic
      self-saving chain reaction, which is crucial to facilitating the replacement of
      damaged or lost tissue. Recent Advances: An immense amount of research has
      uncovered the underlying mechanisms behind the complex and highly regulated wound
      healing process. In this review, we will dissect the biological process of adult 
      skin wound healing and emphasize the importance of epidermal stem cells during
      the wound healing. Critical Issues: We will comprehensively discuss the current
      clinical practices used on patients with cutaneous wounds, including both
      traditional skin grafting procedures and advanced grafting techniques with
      cultured skin stem cells. The majority of these leading techniques still retain
      some deficiencies during clinical use. Moreover, the regeneration of skin
      appendages after severe injuries remains a challenge in treatment. Future
      Directions: Understanding epidermal stem cells and their essential functions
      during skin wound healing are fundamental components behind the development of
      clinical treatment on patients with cutaneous wounds. It is important to improve 
      the current standard of care and to develop novel techniques improving patient
      outcomes and long-term rehabilitation, which should be the goals of future
      endeavors in the field of skin wound healing.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - Ben May Department for Cancer Research, The University of Chicago, Chicago,
      Illinois.
FAU - Zhang, Jamie
AU  - Zhang J
AD  - Ben May Department for Cancer Research, The University of Chicago, Chicago,
      Illinois.
FAU - Yue, Jiping
AU  - Yue J
AD  - Ben May Department for Cancer Research, The University of Chicago, Chicago,
      Illinois.
FAU - Gou, Xuewen
AU  - Gou X
AD  - Ben May Department for Cancer Research, The University of Chicago, Chicago,
      Illinois.
FAU - Wu, Xiaoyang
AU  - Wu X
AD  - Ben May Department for Cancer Research, The University of Chicago, Chicago,
      Illinois.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Wound Care (New Rochelle)
JT  - Advances in wound care
JID - 101590593
PMC - PMC5592843
OTO - NOTNLM
OT  - epidermal stem cells
OT  - skin
OT  - tissue regeneration
OT  - wound repair
COI - No competing financial interests exist. The content of this article was expressly
      written by the author(s) listed. No ghostwriters were used to write this article.
EDAT- 2017/09/13 06:00
MHDA- 2017/09/13 06:01
CRDT- 2017/09/13 06:00
PHST- 2017/01/27 [received]
PHST- 2017/03/13 [accepted]
AID - 10.1089/wound.2017.0728 [doi]
AID - 10.1089/wound.2017.0728 [pii]
PST - ppublish
SO  - Adv Wound Care (New Rochelle). 2017 Sep 1;6(9):297-307. doi:
      10.1089/wound.2017.0728.