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Analysis of patient data from laboratories during the Ebola virus disease outbreak in Liberia, April 2014 to March 2015.

Abstract An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015. A total of 10,536 traceable individuals were identified, of whom 3,897 were confirmed cases (positive for Ebola virus RNA). There were significant differences in sex, age, and place of residence between confirmed and suspected cases that tested negative for Ebola virus RNA. Age (young children and the elderly) and place of residence (rural areas) were the risk factors for death due to the disease. The case fatality rate of confirmed cases decreased from 80% to 63% during the study period. These findings may help support future investigations and lead to a fuller understanding of the outbreak in Liberia.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28732038
OWN - NLM
STAT- MEDLINE
DA  - 20170721
DCOM- 20170810
LR  - 20170813
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul
TI  - Analysis of patient data from laboratories during the Ebola virus disease
      outbreak in Liberia, April 2014 to March 2015.
PG  - e0005804
LID - 10.1371/journal.pntd.0005804 [doi]
AB  - An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended
      in January 2016. Epidemiological information on the EVD cases was collected and
      managed nationally; however, collection and management of the data were
      challenging at the time because surveillance and reporting systems malfunctioned 
      during the outbreak. EVD diagnostic laboratories, however, were able to register 
      basic demographic and clinical information of patients more systematically. Here 
      we present data on 16,370 laboratory samples that were tested between April 4,
      2014 and March 29, 2015. A total of 10,536 traceable individuals were identified,
      of whom 3,897 were confirmed cases (positive for Ebola virus RNA). There were
      significant differences in sex, age, and place of residence between confirmed and
      suspected cases that tested negative for Ebola virus RNA. Age (young children and
      the elderly) and place of residence (rural areas) were the risk factors for death
      due to the disease. The case fatality rate of confirmed cases decreased from 80% 
      to 63% during the study period. These findings may help support future
      investigations and lead to a fuller understanding of the outbreak in Liberia.
FAU - Furuse, Yuki
AU  - Furuse Y
AUID- ORCID: http://orcid.org/0000-0002-4663-6069
AD  - Frontier Research Institute for Interdisciplinary Sciences, Tohoku University,
      Sendai, Japan.
AD  - Department of Virology, Tohoku University Graduate School of Medicine, Sendai,
      Japan.
FAU - Fallah, Mosoka
AU  - Fallah M
AD  - Ministry of Health and Social Welfare, Monrovia, Liberia.
FAU - Oshitani, Hitoshi
AU  - Oshitani H
AD  - Department of Virology, Tohoku University Graduate School of Medicine, Sendai,
      Japan.
FAU - Kituyi, Ling
AU  - Kituyi L
AD  - United Nations Office at Nairobi, Nairobi, Kenya.
FAU - Mahmoud, Nuha
AU  - Mahmoud N
AD  - World Health Organization, Monrovia, Liberia.
FAU - Musa, Emmanuel
AU  - Musa E
AD  - World Health Organization, Monrovia, Liberia.
FAU - Gasasira, Alex
AU  - Gasasira A
AD  - World Health Organization, Monrovia, Liberia.
FAU - Nyenswah, Tolbert
AU  - Nyenswah T
AD  - Ministry of Health and Social Welfare, Monrovia, Liberia.
FAU - Dahn, Bernice
AU  - Dahn B
AD  - Ministry of Health and Social Welfare, Monrovia, Liberia.
FAU - Bawo, Luke
AU  - Bawo L
AD  - Ministry of Health and Social Welfare, Monrovia, Liberia.
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20170721
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Child
MH  - Child, Preschool
MH  - Demography
MH  - Disease Outbreaks/*history
MH  - Ebolavirus/*isolation & purification
MH  - Female
MH  - Hemorrhagic Fever, Ebola/*diagnosis/*mortality
MH  - History, 21st Century
MH  - Humans
MH  - Laboratories
MH  - Liberia/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Mass Screening/methods
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Distribution
MH  - Young Adult
PMC - PMC5540615
EDAT- 2017/07/22 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/05/03 [received]
PHST- 2017/07/12 [accepted]
PHST- 2017/08/02 [revised]
AID - 10.1371/journal.pntd.0005804 [doi]
AID - PNTD-D-17-00704 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Jul 21;11(7):e0005804. doi:
      10.1371/journal.pntd.0005804. eCollection 2017 Jul.