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Resolution of Cheyne-Stokes Respiration after Treatment of Heart Failure with Sacubitril/Valsartan: A First Case Report.

Abstract Sleep-disordered breathing (SDB) is highly prevalent in patients with heart failure (HF), and is known to be associated with a worse prognosis. The severity of central sleep apnea is thought to mirror cardiac dysfunction. The novel angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to improve HF, but a relationship between treatment with ARNi and the severity of SDB has not yet been investigated. We report the case of a 71-year-old male with HF and SDB. Treatment with sacubitril/valsartan was associated with improved cardiac function, as shown by a reduction in the level of N-terminal prohormone of brain natriuretic peptide from 3,249 to 1,720 pg/mL, and an improvement in left-ventricular ejection fraction from 30 to 35%. This was accompanied by a marked reduction in the apnea-hypopnea index (from 41 to 19/h). To the best of our knowledge, this is the first case to document parallel improvements in HF and SDB after the initiation of ARNi treatment.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title cardiology
Publication Year Start




PMID- 28178694
OWN - NLM
STAT- Publisher
DA  - 20170208
LR  - 20170208
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 137
IP  - 2
DP  - 2017 Feb 09
TI  - Resolution of Cheyne-Stokes Respiration after Treatment of Heart Failure with
      Sacubitril/Valsartan: A First Case Report.
PG  - 96-99
LID - 10.1159/000455118 [doi]
AB  - Sleep-disordered breathing (SDB) is highly prevalent in patients with heart
      failure (HF), and is known to be associated with a worse prognosis. The severity 
      of central sleep apnea is thought to mirror cardiac dysfunction. The novel
      angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to
      improve HF, but a relationship between treatment with ARNi and the severity of
      SDB has not yet been investigated. We report the case of a 71-year-old male with 
      HF and SDB. Treatment with sacubitril/valsartan was associated with improved
      cardiac function, as shown by a reduction in the level of N-terminal prohormone
      of brain natriuretic peptide from 3,249 to 1,720 pg/mL, and an improvement in
      left-ventricular ejection fraction from 30 to 35%. This was accompanied by a
      marked reduction in the apnea-hypopnea index (from 41 to 19/h). To the best of
      our knowledge, this is the first case to document parallel improvements in HF and
      SDB after the initiation of ARNi treatment.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Fox, Henrik
AU  - Fox H
AD  - Clinic for Cardiology, Herz- und Diabeteszentrum NRW, Ruhr-Universitat Bochum,
      Bad Oeynhausen, Germany.
FAU - Bitter, Thomas
AU  - Bitter T
FAU - Horstkotte, Dieter
AU  - Horstkotte D
FAU - Oldenburg, Olaf
AU  - Oldenburg O
LA  - eng
PT  - Journal Article
DEP - 20170209
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
EDAT- 2017/02/09 06:00
MHDA- 2017/02/09 06:00
CRDT- 2017/02/09 06:00
PHST- 2016/12/15 [received]
PHST- 2016/12/15 [accepted]
AID - 000455118 [pii]
AID - 10.1159/000455118 [doi]
PST - aheadofprint
SO  - Cardiology. 2017 Feb 9;137(2):96-99. doi: 10.1159/000455118.

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