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Hyperbaric Oxygen Prevents Cognitive Impairments in Mice Induced by D-Galactose by Improving Cholinergic and Anti-apoptotic Functions.

Abstract Our previous study demonstrated that hyperbaric oxygen (HBO) improved cognitive impairments mainly by regulating oxidative stress, inflammatory responses and aging-related gene expression. However, a method for preventing cognitive dysfunction has yet to be developed. In the present study, we explored the protective effects of HBO on the cholinergic system and apoptosis in D-galactose (D-gal)-treated mice. A model of aging was established via systemic intraperitoneal injection of D-gal daily for 8 weeks. HBO was administered during the last 2 weeks of D-gal injection. Our results showed that HBO in D-gal-treated mice significantly improved behavioral performance on the open field test and passive avoidance task. Studies on the potential mechanisms of this effect showed that HBO significantly reduced oxidative stress and blocked the nuclear factor-κB pathway. Moreover, HBO significantly increased the levels of choline acetyltransferase and acetylcholine and decreased the activity of acetylcholinesterase in the hippocampus. Furthermore, HBO markedly increased expression of the anti-apoptosis protein Bcl-2 and glial fibrillary acidic protein meanwhile decreased expression of the pro-apoptosis proteins Bax and caspase-3. Importantly, there was a significant reduction in expression of Aβ-related genes, such as amyloid precursor protein, β-site amyloid cleaving enzyme-1 and cathepsin B mRNA. These decreases were accompanied by significant increases in expression of neprilysin and insulin-degrading enzyme mRNA. Moreover, compared with the Vitamin E group, HBO combined with Vitamin E exhibited significant difference in part of the above mention parameters. These findings suggest that HBO may act as a neuroprotective agent in preventing cognitive impairments.
PMID
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Protective Effect of Hyperbaric Oxygen on Cognitive Impairment Induced by D-Galactose in Mice.

Authors

Mayor MeshTerms
Keywords

Apoptosis

Aβ-related genes

Cholinergic system

D-galactose

Hyperbaric oxygen

Journal Title neurochemical research
Publication Year Start




PMID- 28078611
OWN - NLM
STAT- Publisher
DA  - 20170112
LR  - 20170112
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
DP  - 2017 Jan 11
TI  - Hyperbaric Oxygen Prevents Cognitive Impairments in Mice Induced by D-Galactose
      by Improving Cholinergic and Anti-apoptotic Functions.
LID - 10.1007/s11064-016-2166-8 [doi]
AB  - Our previous study demonstrated that hyperbaric oxygen (HBO) improved cognitive
      impairments mainly by regulating oxidative stress, inflammatory responses and
      aging-related gene expression. However, a method for preventing cognitive
      dysfunction has yet to be developed. In the present study, we explored the
      protective effects of HBO on the cholinergic system and apoptosis in D-galactose 
      (D-gal)-treated mice. A model of aging was established via systemic
      intraperitoneal injection of D-gal daily for 8 weeks. HBO was administered during
      the last 2 weeks of D-gal injection. Our results showed that HBO in D-gal-treated
      mice significantly improved behavioral performance on the open field test and
      passive avoidance task. Studies on the potential mechanisms of this effect showed
      that HBO significantly reduced oxidative stress and blocked the nuclear
      factor-kappaB pathway. Moreover, HBO significantly increased the levels of
      choline acetyltransferase and acetylcholine and decreased the activity of
      acetylcholinesterase in the hippocampus. Furthermore, HBO markedly increased
      expression of the anti-apoptosis protein Bcl-2 and glial fibrillary acidic
      protein meanwhile decreased expression of the pro-apoptosis proteins Bax and
      caspase-3. Importantly, there was a significant reduction in expression of
      Abeta-related genes, such as amyloid precursor protein, beta-site amyloid
      cleaving enzyme-1 and cathepsin B mRNA. These decreases were accompanied by
      significant increases in expression of neprilysin and insulin-degrading enzyme
      mRNA. Moreover, compared with the Vitamin E group, HBO combined with Vitamin E
      exhibited significant difference in part of the above mention parameters. These
      findings suggest that HBO may act as a neuroprotective agent in preventing
      cognitive impairments.
FAU - Chen, Chunxia
AU  - Chen C
AD  - Department of Hyperbaric oxygen, The People's Hospital of Guangxi Zhuang
      Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Huang, Luying
AU  - Huang L
AD  - Department of Respiratory Diseases, The People's Hospital of Guangxi Zhuang
      Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Nong, Zhihuan
AU  - Nong Z
AD  - Department of Pharmacology, Guangxi Institute of Chinese Medicine and
      Pharmaceutical Science, Nanning, 530022, People's Republic of China.
FAU - Li, Yaoxuan
AU  - Li Y
AD  - Department of Neurology, The People's Hospital of Guangxi Zhuang Autonomous
      Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Chen, Wan
AU  - Chen W
AD  - Department of Emergency, The People's Hospital of Guangxi Zhuang Autonomous
      Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Huang, Jianping
AU  - Huang J
AD  - Department of Hyperbaric oxygen, The People's Hospital of Guangxi Zhuang
      Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Pan, Xiaorong
AU  - Pan X
AD  - Department of Hyperbaric oxygen, The People's Hospital of Guangxi Zhuang
      Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Wu, Guangwei
AU  - Wu G
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous
      Region, 6 Taoyuan Road, Nanning, 530021, Guangxi, People's Republic of China.
FAU - Lin, Yingzhong
AU  - Lin Y
AD  - Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous
      Region, 6 Taoyuan Road, Nanning, 530021, Guangxi, People's Republic of China.
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170111
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
OTO - NOTNLM
OT  - Apoptosis
OT  - Abeta-related genes
OT  - Cholinergic system
OT  - D-galactose
OT  - Hyperbaric oxygen
EDAT- 2017/01/13 06:00
MHDA- 2017/01/13 06:00
CRDT- 2017/01/13 06:00
PHST- 2016/11/19 [received]
PHST- 2016/12/22 [accepted]
PHST- 2016/12/21 [revised]
AID - 10.1007/s11064-016-2166-8 [doi]
AID - 10.1007/s11064-016-2166-8 [pii]
PST - aheadofprint
SO  - Neurochem Res. 2017 Jan 11. doi: 10.1007/s11064-016-2166-8.

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