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Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016.

Abstract CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others (2). Recommended infant laboratory evaluation includes both molecular (real-time reverse transcription-polymerase chain reaction [rRT-PCR]) and serologic (immunoglobulin M [IgM]) testing. Initial samples should be collected directly from the infant in the first 2 days of life, if possible; testing of cord blood is not recommended. A positive infant serum or urine rRT-PCR test result confirms congenital Zika virus infection. Positive Zika virus IgM testing, with a negative rRT-PCR result, indicates probable congenital Zika virus infection. In addition to infant Zika virus testing, initial evaluation of all infants born to mothers with laboratory evidence of Zika virus infection during pregnancy should include a comprehensive physical examination, including a neurologic examination, postnatal head ultrasound, and standard newborn hearing screen. Infants with laboratory evidence of congenital Zika virus infection should have a comprehensive ophthalmologic exam and hearing assessment by auditory brainstem response (ABR) testing before 1 month of age. Recommendations for follow-up of infants with laboratory evidence of congenital Zika virus infection depend on whether abnormalities consistent with congenital Zika syndrome are present. Infants with abnormalities consistent with congenital Zika syndrome should have a coordinated evaluation by multiple specialists within the first month of life; additional evaluations will be needed within the first year of life, including assessments of vision, hearing, feeding, growth, and neurodevelopmental and endocrine function. Families and caregivers will also need ongoing psychosocial support and assistance with coordination of care. Infants with laboratory evidence of congenital Zika virus infection without apparent abnormalities should have ongoing developmental monitoring and screening by the primary care provider; repeat hearing testing is recommended. This guidance will be updated when additional information becomes available.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title mmwr. morbidity and mortality weekly report
Publication Year Start

@Article{Russell2016,
author="Russell, Kate
and Oliver, Sara E.
and Lewis, Lillianne
and Barfield, Wanda D.
and Cragan, Janet
and Meaney-Delman, Dana
and Staples, J. Erin
and Fischer, Marc
and Peacock, Georgina
and Oduyebo, Titilope
and Petersen, Emily E.
and Zaki, Sherif
and Moore, Cynthia A.
and Rasmussen, Sonja A.
and {Contributors}
and {Boston Children's Hospital}
and {RTI International}
and {University of Utah}
and {Administration for Children and Families}
and {Augusta University}
and {Family Voices, Inc.}
and {Seattle Children's Hospital}
and {Center for Medicaid and CHIP Services}
and {Centers for Medicare and Medicaid Services}
and {CDC}
and {Tift Regional Health System}
and {Texas Department of State Health Services}
and {Duke University}
and {University of Pittsburgh}
and {Cincinnati Children's Hospital}
and {University of Rochester Medical Center}
and {Office of the Assistant Secretary for Health}
and {National Institute of Child Health and Human Development}
and {Nemours Children's Health System}
and {Sidney Kimmel Medical College of Thomas Jefferson University}
and {Maternal and Child Health Bureau}
and {Health Resources and Services Administration}
and {Stanford University}
and {March of Dimes}
and {University of Chicago}
and {Florida State University College of Medicine}
and {University of Chicago Medicine-Comer Children's Hospital}
and {Elizabeth Glaser Pediatric AIDS Foundation}
and {Parent to Parent of Georgia}
and {Healthcare Network of Southwest Florida}
and {University of Arizona}
and {University of Florida}
and {Emory University}
and {University of California, San Diego}
and {Nationwide Children's Hospital}
and {University of Mississippi Medical Center}
and {University of Texas Southwestern Medical Center}
and {University of Wisconsin, Madison}
and {American Academy of Pediatrics (AAP}
and {Vanderbilt University School of Medicine}
and {Altino Ventura Foundation}
and {Children's of Alabama,}
and {University of Alabama at Birmingham}
and {Cincinnati Children's Hospital Medical Center}
and {Puerto Rico Chapter, AAP.}",
title="Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016.",
journal="MMWR. Morbidity and mortality weekly report",
year="2016",
month="Aug",
day="26",
volume="65",
number="33",
pages="870--878",
abstract="CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others (2). Recommended infant laboratory evaluation includes both molecular (real-time reverse transcription-polymerase chain reaction [rRT-PCR]) and serologic (immunoglobulin M [IgM]) testing. Initial samples should be collected directly from the infant in the first 2 days of life, if possible; testing of cord blood is not recommended. A positive infant serum or urine rRT-PCR test result confirms congenital Zika virus infection. Positive Zika virus IgM testing, with a negative rRT-PCR result, indicates probable congenital Zika virus infection. In addition to infant Zika virus testing, initial evaluation of all infants born to mothers with laboratory evidence of Zika virus infection during pregnancy should include a comprehensive physical examination, including a neurologic examination, postnatal head ultrasound, and standard newborn hearing screen. Infants with laboratory evidence of congenital Zika virus infection should have a comprehensive ophthalmologic exam and hearing assessment by auditory brainstem response (ABR) testing before 1 month of age. Recommendations for follow-up of infants with laboratory evidence of congenital Zika virus infection depend on whether abnormalities consistent with congenital Zika syndrome are present. Infants with abnormalities consistent with congenital Zika syndrome should have a coordinated evaluation by multiple specialists within the first month of life; additional evaluations will be needed within the first year of life, including assessments of vision, hearing, feeding, growth, and neurodevelopmental and endocrine function. Families and caregivers will also need ongoing psychosocial support and assistance with coordination of care. Infants with laboratory evidence of congenital Zika virus infection without apparent abnormalities should have ongoing developmental monitoring and screening by the primary care provider; repeat hearing testing is recommended. This guidance will be updated when additional information becomes available.",
issn="1545-861X",
doi="10.15585/mmwr.mm6533e2",
url="http://www.ncbi.nlm.nih.gov/pubmed/27559830",
language="ENG"
}


PT Journal
AU Russell, K
   Oliver, SE
   Lewis, L
   Barfield, WD
   Cragan, J
   Meaney-Delman, D
   Staples, JE
   Fischer, M
   Peacock, G
   Oduyebo, T
   Petersen, EE
   Zaki, S
   Moore, CA
   Rasmussen, SA
AU Contributors
AU Boston Children?s Hospital
AU RTI International
AU University of Utah
AU Administration for Children and Families
AU Augusta University
AU Family Voices, Inc.
AU Seattle Children?s Hospital
AU Center for Medicaid and CHIP Services
AU Centers for Medicare and Medicaid Services
AU CDC
AU Tift Regional Health System
AU Texas Department of State Health Services
AU Duke University
AU University of Pittsburgh
AU Cincinnati Children?s Hospital
AU University of Rochester Medical Center
AU Office of the Assistant Secretary for Health
AU National Institute of Child Health and Human Development
AU Nemours Children?s Health System
AU Sidney Kimmel Medical College of Thomas Jefferson University
AU Maternal and Child Health Bureau
AU Health Resources and Services Administration
AU Stanford University
AU March of Dimes
AU University of Chicago
AU Florida State University College of Medicine
AU University of Chicago Medicine-Comer Children?s Hospital
AU Elizabeth Glaser Pediatric AIDS Foundation
AU Parent to Parent of Georgia
AU Healthcare Network of Southwest Florida
AU University of Arizona
AU University of Florida
AU Emory University
AU University of California, San Diego
AU Nationwide Children?s Hospital
AU University of Mississippi Medical Center
AU University of Texas Southwestern Medical Center
AU University of Wisconsin, Madison
AU American Academy of Pediatrics (AAP
AU Vanderbilt University School of Medicine
AU Altino Ventura Foundation
AU Children?s of Alabama,
AU University of Alabama at Birmingham
AU Cincinnati Children?s Hospital Medical Center
AU Puerto Rico Chapter, AAP.
TI Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016.
SO MMWR. Morbidity and mortality weekly report
JI MMWR Morb. Mortal. Wkly. Rep.
PD 8
PY 2016
BP 870
EP 878
VL 65
IS 33
DI 10.15585/mmwr.mm6533e2
LA ENG
AB CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others (2). Recommended infant laboratory evaluation includes both molecular (real-time reverse transcription-polymerase chain reaction [rRT-PCR]) and serologic (immunoglobulin M [IgM]) testing. Initial samples should be collected directly from the infant in the first 2 days of life, if possible; testing of cord blood is not recommended. A positive infant serum or urine rRT-PCR test result confirms congenital Zika virus infection. Positive Zika virus IgM testing, with a negative rRT-PCR result, indicates probable congenital Zika virus infection. In addition to infant Zika virus testing, initial evaluation of all infants born to mothers with laboratory evidence of Zika virus infection during pregnancy should include a comprehensive physical examination, including a neurologic examination, postnatal head ultrasound, and standard newborn hearing screen. Infants with laboratory evidence of congenital Zika virus infection should have a comprehensive ophthalmologic exam and hearing assessment by auditory brainstem response (ABR) testing before 1 month of age. Recommendations for follow-up of infants with laboratory evidence of congenital Zika virus infection depend on whether abnormalities consistent with congenital Zika syndrome are present. Infants with abnormalities consistent with congenital Zika syndrome should have a coordinated evaluation by multiple specialists within the first month of life; additional evaluations will be needed within the first year of life, including assessments of vision, hearing, feeding, growth, and neurodevelopmental and endocrine function. Families and caregivers will also need ongoing psychosocial support and assistance with coordination of care. Infants with laboratory evidence of congenital Zika virus infection without apparent abnormalities should have ongoing developmental monitoring and screening by the primary care provider; repeat hearing testing is recommended. This guidance will be updated when additional information becomes available.
ER


TY  - JOUR
AU  - Russell, Kate
AU  - Oliver, Sara E.
AU  - Lewis, Lillianne
AU  - Barfield, Wanda D.
AU  - Cragan, Janet
AU  - Meaney-Delman, Dana
AU  - Staples, J. Erin
AU  - Fischer, Marc
AU  - Peacock, Georgina
AU  - Oduyebo, Titilope
AU  - Petersen, Emily E.
AU  - Zaki, Sherif
AU  - Moore, Cynthia A.
AU  - Rasmussen, Sonja A.
AU  - Contributors
AU  - Boston Children?s Hospital
AU  - RTI International
AU  - University of Utah
AU  - Administration for Children and Families
AU  - Augusta University
AU  - Family Voices, Inc.
AU  - Seattle Children?s Hospital
AU  - Center for Medicaid and CHIP Services
AU  - Centers for Medicare and Medicaid Services
AU  - CDC
AU  - Tift Regional Health System
AU  - Texas Department of State Health Services
AU  - Duke University
AU  - University of Pittsburgh
AU  - Cincinnati Children?s Hospital
AU  - University of Rochester Medical Center
AU  - Office of the Assistant Secretary for Health
AU  - National Institute of Child Health and Human Development
AU  - Nemours Children?s Health System
AU  - Sidney Kimmel Medical College of Thomas Jefferson University
AU  - Maternal and Child Health Bureau
AU  - Health Resources and Services Administration
AU  - Stanford University
AU  - March of Dimes
AU  - University of Chicago
AU  - Florida State University College of Medicine
AU  - University of Chicago Medicine-Comer Children?s Hospital
AU  - Elizabeth Glaser Pediatric AIDS Foundation
AU  - Parent to Parent of Georgia
AU  - Healthcare Network of Southwest Florida
AU  - University of Arizona
AU  - University of Florida
AU  - Emory University
AU  - University of California, San Diego
AU  - Nationwide Children?s Hospital
AU  - University of Mississippi Medical Center
AU  - University of Texas Southwestern Medical Center
AU  - University of Wisconsin, Madison
AU  - American Academy of Pediatrics (AAP
AU  - Vanderbilt University School of Medicine
AU  - Altino Ventura Foundation
AU  - Children?s of Alabama,
AU  - University of Alabama at Birmingham
AU  - Cincinnati Children?s Hospital Medical Center
AU  - Puerto Rico Chapter, AAP.
PY  - 2016/08/26
TI  - Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016.
T2  - MMWR Morb. Mortal. Wkly. Rep.
JO  - MMWR. Morbidity and mortality weekly report
SP  - 870
EP  - 878
VL  - 65
IS  - 33
N2  - CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others (2). Recommended infant laboratory evaluation includes both molecular (real-time reverse transcription-polymerase chain reaction [rRT-PCR]) and serologic (immunoglobulin M [IgM]) testing. Initial samples should be collected directly from the infant in the first 2 days of life, if possible; testing of cord blood is not recommended. A positive infant serum or urine rRT-PCR test result confirms congenital Zika virus infection. Positive Zika virus IgM testing, with a negative rRT-PCR result, indicates probable congenital Zika virus infection. In addition to infant Zika virus testing, initial evaluation of all infants born to mothers with laboratory evidence of Zika virus infection during pregnancy should include a comprehensive physical examination, including a neurologic examination, postnatal head ultrasound, and standard newborn hearing screen. Infants with laboratory evidence of congenital Zika virus infection should have a comprehensive ophthalmologic exam and hearing assessment by auditory brainstem response (ABR) testing before 1 month of age. Recommendations for follow-up of infants with laboratory evidence of congenital Zika virus infection depend on whether abnormalities consistent with congenital Zika syndrome are present. Infants with abnormalities consistent with congenital Zika syndrome should have a coordinated evaluation by multiple specialists within the first month of life; additional evaluations will be needed within the first year of life, including assessments of vision, hearing, feeding, growth, and neurodevelopmental and endocrine function. Families and caregivers will also need ongoing psychosocial support and assistance with coordination of care. Infants with laboratory evidence of congenital Zika virus infection without apparent abnormalities should have ongoing developmental monitoring and screening by the primary care provider; repeat hearing testing is recommended. This guidance will be updated when additional information becomes available.
SN  - 1545-861X
UR  - http://dx.doi.org/10.15585/mmwr.mm6533e2
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27559830
ID  - Russell2016
ER  -