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Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.

Abstract We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).
PMID
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Authors

Mayor MeshTerms

Disability Evaluation

Geography

Patient Preference

Sex Characteristics

Withholding Treatment

Keywords
Journal Title plos one
Publication Year Start
%A Meyniel, Claire; Spelman, Timothy; Jokubaitis, Vilija G.; Trojano, Maria; Izquierdo, Guillermo; Grand'Maison, Fran?ois; Oreja-Guevara, Celia; Boz, Cavit; Lugaresi, Alessandra; Girard, Marc; Grammond, Pierre; Iuliano, Gerardo; Fiol, Marcela; Cabrera-Gomez, Jose Antonio; Fernandez-Bolanos, Ricardo; Giuliani, Giorgio; Lechner-Scott, Jeannette; Cristiano, Edgardo; Herbert, Joseph; Petkovska-Boskova, Tatjana; Bergamaschi, Roberto; van Pesch, Vincent; Moore, Fraser; Vella, Norbert; Slee, Mark; Santiago, Vetere; Barnett, Michael; Havrdova, Eva; Young, Carolyn; Sirbu, Carmen-Adella; Tanner, Mary; Rutherford, Michelle; Butzkueven, Helmut
%A MSBasis Study Group
%T Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.
%J PloS one, vol. 7, no. 6, p. e38661
%D 06/2012
%V 7
%N 6
%M eng
%B We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).
%K Adult, Decision Making, Disability Evaluation, Female, Geography, Humans, Immunologic Factors, Kaplan-Meier Estimate, Male, Multiple Sclerosis, Relapsing-Remitting, Patient Preference, Prognosis, Proportional Hazards Models, Sex Characteristics, Withholding Treatment
%P e38661
%Y 10.1371/journal.pone.0038661
%W PHY
%G AUTHOR
%R 2012PLoSO...7....0M

@Article{Meyniel2012,
author="Meyniel, Claire
and Spelman, Timothy
and Jokubaitis, Vilija G.
and Trojano, Maria
and Izquierdo, Guillermo
and Grand'Maison, Fran{\c{c}}ois
and Oreja-Guevara, Celia
and Boz, Cavit
and Lugaresi, Alessandra
and Girard, Marc
and Grammond, Pierre
and Iuliano, Gerardo
and Fiol, Marcela
and Cabrera-Gomez, Jose Antonio
and Fernandez-Bolanos, Ricardo
and Giuliani, Giorgio
and Lechner-Scott, Jeannette
and Cristiano, Edgardo
and Herbert, Joseph
and Petkovska-Boskova, Tatjana
and Bergamaschi, Roberto
and van Pesch, Vincent
and Moore, Fraser
and Vella, Norbert
and Slee, Mark
and Santiago, Vetere
and Barnett, Michael
and Havrdova, Eva
and Young, Carolyn
and Sirbu, Carmen-Adella
and Tanner, Mary
and Rutherford, Michelle
and Butzkueven, Helmut
and {MSBasis Study Group}",
title="Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.",
journal="PloS one",
year="2012",
month="Jun",
day="29",
volume="7",
number="6",
pages="e38661",
keywords="Adult",
keywords="Decision Making",
keywords="Disability Evaluation",
keywords="Female",
keywords="Geography",
keywords="Humans",
keywords="Immunologic Factors",
keywords="Kaplan-Meier Estimate",
keywords="Male",
keywords="Multiple Sclerosis, Relapsing-Remitting",
keywords="Patient Preference",
keywords="Prognosis",
keywords="Proportional Hazards Models",
keywords="Sex Characteristics",
keywords="Withholding Treatment",
abstract="We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).",
issn="1932-6203",
doi="10.1371/journal.pone.0038661",
url="http://www.ncbi.nlm.nih.gov/pubmed/22768046",
language="eng"
}

%0 Journal Article
%T Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.
%A Meyniel, Claire
%A Spelman, Timothy
%A Jokubaitis, Vilija G.
%A Trojano, Maria
%A Izquierdo, Guillermo
%A Grand'Maison, Fran?ois
%A Oreja-Guevara, Celia
%A Boz, Cavit
%A Lugaresi, Alessandra
%A Girard, Marc
%A Grammond, Pierre
%A Iuliano, Gerardo
%A Fiol, Marcela
%A Cabrera-Gomez, Jose Antonio
%A Fernandez-Bolanos, Ricardo
%A Giuliani, Giorgio
%A Lechner-Scott, Jeannette
%A Cristiano, Edgardo
%A Herbert, Joseph
%A Petkovska-Boskova, Tatjana
%A Bergamaschi, Roberto
%A van Pesch, Vincent
%A Moore, Fraser
%A Vella, Norbert
%A Slee, Mark
%A Santiago, Vetere
%A Barnett, Michael
%A Havrdova, Eva
%A Young, Carolyn
%A Sirbu, Carmen-Adella
%A Tanner, Mary
%A Rutherford, Michelle
%A Butzkueven, Helmut
%A MSBasis Study Group
%J PloS one
%D 2012
%8 June 29
%V 7
%N 6
%@ 1932-6203
%G eng
%F Meyniel2012
%X We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).
%K Adult
%K Decision Making
%K Disability Evaluation
%K Female
%K Geography
%K Humans
%K Immunologic Factors
%K Kaplan-Meier Estimate
%K Male
%K Multiple Sclerosis, Relapsing-Remitting
%K Patient Preference
%K Prognosis
%K Proportional Hazards Models
%K Sex Characteristics
%K Withholding Treatment
%U http://dx.doi.org/10.1371/journal.pone.0038661
%U http://www.ncbi.nlm.nih.gov/pubmed/22768046
%P e38661

PT Journal
AU Meyniel, C
   Spelman, T
   Jokubaitis, VG
   Trojano, M
   Izquierdo, G
   Grand'Maison, F
   Oreja-Guevara, C
   Boz, C
   Lugaresi, A
   Girard, M
   Grammond, P
   Iuliano, G
   Fiol, M
   Cabrera-Gomez, JA
   Fernandez-Bolanos, R
   Giuliani, G
   Lechner-Scott, J
   Cristiano, E
   Herbert, J
   Petkovska-Boskova, T
   Bergamaschi, R
   van Pesch, V
   Moore, F
   Vella, N
   Slee, M
   Santiago, V
   Barnett, M
   Havrdova, E
   Young, C
   Sirbu, C
   Tanner, M
   Rutherford, M
   Butzkueven, H
AU MSBasis Study Group
TI Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.
SO PloS one
JI PLoS ONE
PD 06
PY 2012
BP e38661
VL 7
IS 6
DI 10.1371/journal.pone.0038661
LA eng
DE Adult; Decision Making; Disability Evaluation; Female; Geography; Humans; Immunologic Factors; Kaplan-Meier Estimate; Male; Multiple Sclerosis, Relapsing-Remitting; Patient Preference; Prognosis; Proportional Hazards Models; Sex Characteristics; Withholding Treatment
AB We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).
ER

PMID- 22768046
OWN - NLM
STAT- MEDLINE
DA  - 20120706
DCOM- 20121127
LR  - 20150224
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Country, sex, EDSS change and therapy choice independently predict treatment
      discontinuation in multiple sclerosis and clinically isolated syndrome.
PG  - e38661
LID - 10.1371/journal.pone.0038661 [doi]
AB  - OBJECTIVES: We conducted a prospective study, MSBASIS, to assess factors leading 
      to first treatment discontinuation in patients with a clinically isolated
      syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS). METHODS: 
      The MSBASIS Study, conducted by MSBase Study Group members, enrols patients seen 
      from CIS onset, reporting baseline demographics, cerebral magnetic resonance
      imaging (MRI) features and Expanded Disability Status Scale (EDSS) scores.
      Follow-up visits report relapses, EDSS scores, and the start and end dates of
      MS-specific therapies. We performed a multivariable survival analysis to
      determine factors within this dataset that predict first treatment
      discontinuation. RESULTS: A total of 2314 CIS patients from 44 centres were
      followed for a median of 2.7 years, during which time 1247 commenced
      immunomodulatory drug (IMD) treatment. Ninety percent initiated IMD after a
      diagnosis of MS was confirmed, and 10% while still in CIS status. Over 40% of
      these patients stopped their first IMD during the observation period. Females
      were more likely to cease medication than males (HR 1.36, p = 0.003). Patients
      treated in Australia were twice as likely to cease their first IMD than patients 
      treated in Spain (HR 1.98, p = 0.001). Increasing EDSS was associated with higher
      rate of IMD cessation (HR 1.21 per EDSS unit, p<0.001), and intramuscular
      interferon-beta-1a (HR 1.38, p = 0.028) and subcutaneous interferon-beta-1a (HR
      1.45, p = 0.012) had higher rates of discontinuation than glatiramer acetate,
      although this varied widely in different countries. Onset cerebral MRI features, 
      age, time to treatment initiation or relapse on treatment were not associated
      with IMD cessation. CONCLUSION: In this multivariable survival analysis, female
      sex, country of residence, EDSS change and IMD choice independently predicted
      time to first IMD cessation.
FAU - Meyniel, Claire
AU  - Meyniel C
AD  - Department of Neurology, Royal Melbourne Hospital, Victoria, Australia.
FAU - Spelman, Timothy
AU  - Spelman T
FAU - Jokubaitis, Vilija G
AU  - Jokubaitis VG
FAU - Trojano, Maria
AU  - Trojano M
FAU - Izquierdo, Guillermo
AU  - Izquierdo G
FAU - Grand'Maison, Francois
AU  - Grand'Maison F
FAU - Oreja-Guevara, Celia
AU  - Oreja-Guevara C
FAU - Boz, Cavit
AU  - Boz C
FAU - Lugaresi, Alessandra
AU  - Lugaresi A
FAU - Girard, Marc
AU  - Girard M
FAU - Grammond, Pierre
AU  - Grammond P
FAU - Iuliano, Gerardo
AU  - Iuliano G
FAU - Fiol, Marcela
AU  - Fiol M
FAU - Cabrera-Gomez, Jose Antonio
AU  - Cabrera-Gomez JA
FAU - Fernandez-Bolanos, Ricardo
AU  - Fernandez-Bolanos R
FAU - Giuliani, Giorgio
AU  - Giuliani G
FAU - Lechner-Scott, Jeannette
AU  - Lechner-Scott J
FAU - Cristiano, Edgardo
AU  - Cristiano E
FAU - Herbert, Joseph
AU  - Herbert J
FAU - Petkovska-Boskova, Tatjana
AU  - Petkovska-Boskova T
FAU - Bergamaschi, Roberto
AU  - Bergamaschi R
FAU - van Pesch, Vincent
AU  - van Pesch V
FAU - Moore, Fraser
AU  - Moore F
FAU - Vella, Norbert
AU  - Vella N
FAU - Slee, Mark
AU  - Slee M
FAU - Santiago, Vetere
AU  - Santiago V
FAU - Barnett, Michael
AU  - Barnett M
FAU - Havrdova, Eva
AU  - Havrdova E
FAU - Young, Carolyn
AU  - Young C
FAU - Sirbu, Carmen-Adella
AU  - Sirbu CA
FAU - Tanner, Mary
AU  - Tanner M
FAU - Rutherford, Michelle
AU  - Rutherford M
FAU - Butzkueven, Helmut
AU  - Butzkueven H
CN  - MSBasis Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120629
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - *Disability Evaluation
MH  - Female
MH  - *Geography
MH  - Humans
MH  - Immunologic Factors/therapeutic use
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Multiple Sclerosis, Relapsing-Remitting/*drug therapy
MH  - *Patient Preference
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - *Sex Characteristics
MH  - *Withholding Treatment
PMC - PMC3387159
OID - NLM: PMC3387159
IR  - Paolicelli D
FIR - Paolicelli, Damiano
IR  - Lucchese G
FIR - Lucchese, Guglielmo
IR  - Iaffaldano P
FIR - Iaffaldano, Pietro
IR  - Marriott M
FIR - Marriott, Mark
IR  - Kilpatrick T
FIR - Kilpatrick, Trevor
IR  - King J
FIR - King, John
IR  - Van der Walt A
FIR - Van der Walt, Anneke
IR  - Haartsen J
FIR - Haartsen, Jodi
IR  - Skibina O
FIR - Skibina, Olga
IR  - Zwanikken C
FIR - Zwanikken, Cees
IR  - De Luca G
FIR - De Luca, Giovanna
IR  - Di Tommaso V
FIR - Di Tommaso, Valeria
IR  - Travaglini D
FIR - Travaglini, Daniela
IR  - Pietrolongo E
FIR - Pietrolongo, Erika
IR  - di Ioia M
FIR - di Ioia, Maria
IR  - Farina D
FIR - Farina, Deborah
IR  - Duquette P
FIR - Duquette, Pierre
IR  - Petersen T
FIR - Petersen, Thor
IR  - Hupperts R
FIR - Hupperts, Raymond
IR  - Correale J
FIR - Correale, Jorge
IR  - Ysrraelit C
FIR - Ysrraelit, Celica
IR  - Cartechini E
FIR - Cartechini, Elisabetta
IR  - Pucci E
FIR - Pucci, Eugenio
IR  - Williams D
FIR - Williams, David
IR  - Dark L
FIR - Dark, Lisa
IR  - Verhuel F
FIR - Verhuel, Freek
IR  - Vella M
FIR - Vella, Malcolm
IR  - Saladino ML
FIR - Saladino, Maria Laura
IR  - Paine M
FIR - Paine, Mark
IR  - Shaw C
FIR - Shaw, Cameron
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2011/10/07 [received]
PHST- 2012/05/09 [accepted]
PHST- 2012/06/29 [epublish]
AID - 10.1371/journal.pone.0038661 [doi]
AID - PONE-D-11-20113 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e38661. doi: 10.1371/journal.pone.0038661. Epub 2012 Jun 29.
TY  - JOUR
AU  - Meyniel, Claire
AU  - Spelman, Timothy
AU  - Jokubaitis, Vilija G.
AU  - Trojano, Maria
AU  - Izquierdo, Guillermo
AU  - Grand'Maison, Fran?ois
AU  - Oreja-Guevara, Celia
AU  - Boz, Cavit
AU  - Lugaresi, Alessandra
AU  - Girard, Marc
AU  - Grammond, Pierre
AU  - Iuliano, Gerardo
AU  - Fiol, Marcela
AU  - Cabrera-Gomez, Jose Antonio
AU  - Fernandez-Bolanos, Ricardo
AU  - Giuliani, Giorgio
AU  - Lechner-Scott, Jeannette
AU  - Cristiano, Edgardo
AU  - Herbert, Joseph
AU  - Petkovska-Boskova, Tatjana
AU  - Bergamaschi, Roberto
AU  - van Pesch, Vincent
AU  - Moore, Fraser
AU  - Vella, Norbert
AU  - Slee, Mark
AU  - Santiago, Vetere
AU  - Barnett, Michael
AU  - Havrdova, Eva
AU  - Young, Carolyn
AU  - Sirbu, Carmen-Adella
AU  - Tanner, Mary
AU  - Rutherford, Michelle
AU  - Butzkueven, Helmut
AU  - MSBasis Study Group
PY  - 2012/06/29
TI  - Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome.
T2  - PLoS ONE
JO  - PloS one
SP  - e38661
VL  - 7
IS  - 6
KW  - Adult
KW  - Decision Making
KW  - Disability Evaluation
KW  - Female
KW  - Geography
KW  - Humans
KW  - Immunologic Factors
KW  - Kaplan-Meier Estimate
KW  - Male
KW  - Multiple Sclerosis, Relapsing-Remitting
KW  - Patient Preference
KW  - Prognosis
KW  - Proportional Hazards Models
KW  - Sex Characteristics
KW  - Withholding Treatment
N2  - We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS).
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0038661
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22768046
ID  - Meyniel2012
ER  - 
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