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Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.

Abstract We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title experimental and molecular pathology
Publication Year Start
%A Lee, Kang-Hoon; Chiu, Sophia; Lee, Young-Kwan; Greenhalgh, David G.; Cho, Kiho
%T Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.
%J Experimental and molecular pathology, vol. 93, no. 1, pp. 167-172
%D 08/2012
%V 93
%N 1
%M eng
%B We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.
%K Age Factors, Aging, Animals, Female, Genome Size, Kidney, Liver, Lung, Male, Mice, Mice, Inbred C57BL, Retroelements, Spleen
%P 167
%L 172
%Y 10.1016/j.yexmp.2012.04.013
%W PHY
%G AUTHOR
%R 2012.......93..167L

@Article{Lee2012,
author="Lee, Kang-Hoon
and Chiu, Sophia
and Lee, Young-Kwan
and Greenhalgh, David G.
and Cho, Kiho",
title="Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.",
journal="Experimental and molecular pathology",
year="2012",
month="Aug",
day="20",
volume="93",
number="1",
pages="167--172",
keywords="Age Factors",
keywords="Aging",
keywords="Animals",
keywords="Female",
keywords="Genome Size",
keywords="Kidney",
keywords="Liver",
keywords="Lung",
keywords="Male",
keywords="Mice",
keywords="Mice, Inbred C57BL",
keywords="Retroelements",
keywords="Spleen",
abstract="We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.",
issn="1096-0945",
doi="10.1016/j.yexmp.2012.04.013",
url="http://www.ncbi.nlm.nih.gov/pubmed/22548960",
language="eng"
}

%0 Journal Article
%T Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.
%A Lee, Kang-Hoon
%A Chiu, Sophia
%A Lee, Young-Kwan
%A Greenhalgh, David G.
%A Cho, Kiho
%J Experimental and molecular pathology
%D 2012
%8 Aug 20
%V 93
%N 1
%@ 1096-0945
%G eng
%F Lee2012
%X We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.
%K Age Factors
%K Aging
%K Animals
%K Female
%K Genome Size
%K Kidney
%K Liver
%K Lung
%K Male
%K Mice
%K Mice, Inbred C57BL
%K Retroelements
%K Spleen
%U http://dx.doi.org/10.1016/j.yexmp.2012.04.013
%U http://www.ncbi.nlm.nih.gov/pubmed/22548960
%P 167-172

PT Journal
AU Lee, K
   Chiu, S
   Lee, Y
   Greenhalgh, DG
   Cho, K
TI Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.
SO Experimental and molecular pathology
JI Exp. Mol. Pathol.
PD Aug
PY 2012
BP 167
EP 172
VL 93
IS 1
DI 10.1016/j.yexmp.2012.04.013
LA eng
DE Age Factors; Aging; Animals; Female; Genome Size; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Retroelements; Spleen
AB We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.
ER

PMID- 22548960
OWN - NLM
STAT- MEDLINE
DA  - 20120611
DCOM- 20120824
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Linking)
VI  - 93
IP  - 1
DP  - 2012 Aug
TI  - Age-dependent and tissue-specific structural changes in the C57BL/6J mouse
      genome.
PG  - 167-72
LID - 10.1016/j.yexmp.2012.04.013 [doi]
AB  - We tested the hypothesis that structural changes in the genome parallel age- and 
      organ-specific phenotypes in conjunction with the differential transposition
      activities of retroelements. The genomes of the liver from C57BL/6J mice were
      larger than other organs, coinciding with an increase in genomic copies of
      certain retroelements. In addition, there were differential increments in the
      genome size of the liver with increasing age, which peaked at 5 weeks. The
      findings that the genome structure of an individual is variable depending on age 
      and organ type in association with the transposition of retroelements may have
      broad implications in understanding biologic phenomena.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Lee, Kang-Hoon
AU  - Lee KH
AD  - Shriners Hospitals for Children Northern California and Department of Surgery,
      University of California, Davis, Sacramento, CA 95817, USA.
FAU - Chiu, Sophia
AU  - Chiu S
FAU - Lee, Young-Kwan
AU  - Lee YK
FAU - Greenhalgh, David G
AU  - Greenhalgh DG
FAU - Cho, Kiho
AU  - Cho K
LA  - eng
GR  - R01 GM071360/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120420
PL  - United States
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Retroelements)
SB  - IM
MH  - Age Factors
MH  - Aging/*genetics
MH  - Animals
MH  - Female
MH  - Genome Size/*genetics
MH  - Kidney
MH  - Liver
MH  - Lung
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Retroelements/genetics
MH  - Spleen
EDAT- 2012/05/03 06:00
MHDA- 2012/08/25 06:00
CRDT- 2012/05/03 06:00
PHST- 2012/01/07 [received]
PHST- 2012/03/06 [revised]
PHST- 2012/04/10 [accepted]
PHST- 2012/04/20 [aheadofprint]
AID - S0014-4800(12)00058-5 [pii]
AID - 10.1016/j.yexmp.2012.04.013 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2012 Aug;93(1):167-72. doi: 10.1016/j.yexmp.2012.04.013. Epub
      2012 Apr 20.
TY  - JOUR
AU  - Lee, Kang-Hoon
AU  - Chiu, Sophia
AU  - Lee, Young-Kwan
AU  - Greenhalgh, David G.
AU  - Cho, Kiho
PY  - 2012/Aug/20
TI  - Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.
T2  - Exp. Mol. Pathol.
JO  - Experimental and molecular pathology
SP  - 167
EP  - 172
VL  - 93
IS  - 1
KW  - Age Factors
KW  - Aging
KW  - Animals
KW  - Female
KW  - Genome Size
KW  - Kidney
KW  - Liver
KW  - Lung
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Retroelements
KW  - Spleen
N2  - We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there were differential increments in the genome size of the liver with increasing age, which peaked at 5 weeks. The findings that the genome structure of an individual is variable depending on age and organ type in association with the transposition of retroelements may have broad implications in understanding biologic phenomena.
SN  - 1096-0945
UR  - http://dx.doi.org/10.1016/j.yexmp.2012.04.013
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22548960
ID  - Lee2012
ER  - 
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