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Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.

Abstract Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V?-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.
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Authors

Mayor MeshTerms
Keywords
Journal Title bmc immunology
Publication Year Start
%A Lee, Young-Kwan; Chiu, Sophia; Chew, Alex; Greenhalgh, David G.; Cho, Kiho
%T Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.
%J BMC immunology, vol. 12, p. 5
%D 01/2011
%V 12
%M eng
%B Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V?-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.
%K Animals, Base Sequence, Chromosomes, Mammalian, DNA, Complementary, Female, Genes, Viral, Genetic Loci, Genome, Immune System, Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Mammary Tumor Virus, Mouse, Mice, Mice, Inbred C57BL, Molecular Sequence Annotation, Mutation, Open Reading Frames, Organ Specificity, Phylogeny, Protein Isoforms, Receptors, Antigen, T-Cell, alpha-beta, Superantigens
%P 5
%Y 10.1186/1471-2172-12-5
%W PHY
%G AUTHOR
%R 2011.......12....5L

@Article{Lee2011,
author="Lee, Young-Kwan
and Chiu, Sophia
and Chew, Alex
and Greenhalgh, David G.
and Cho, Kiho",
title="Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.",
journal="BMC immunology",
year="2011",
month="Jan",
day="18",
volume="12",
pages="5",
keywords="Animals",
keywords="Base Sequence",
keywords="Chromosomes, Mammalian",
keywords="DNA, Complementary",
keywords="Female",
keywords="Genes, Viral",
keywords="Genetic Loci",
keywords="Genome",
keywords="Immune System",
keywords="Immunoglobulin Variable Region",
keywords="Immunoglobulin kappa-Chains",
keywords="Mammary Tumor Virus, Mouse",
keywords="Mice",
keywords="Mice, Inbred C57BL",
keywords="Molecular Sequence Annotation",
keywords="Mutation",
keywords="Open Reading Frames",
keywords="Organ Specificity",
keywords="Phylogeny",
keywords="Protein Isoforms",
keywords="Receptors, Antigen, T-Cell, alpha-beta",
keywords="Superantigens",
abstract="Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V$\beta$-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.",
issn="1471-2172",
doi="10.1186/1471-2172-12-5",
url="http://www.ncbi.nlm.nih.gov/pubmed/21244697",
language="eng"
}

%0 Journal Article
%T Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.
%A Lee, Young-Kwan
%A Chiu, Sophia
%A Chew, Alex
%A Greenhalgh, David G.
%A Cho, Kiho
%J BMC immunology
%D 2011
%8 January 18
%V 12
%@ 1471-2172
%G eng
%F Lee2011
%X Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V?-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.
%K Animals
%K Base Sequence
%K Chromosomes, Mammalian
%K DNA, Complementary
%K Female
%K Genes, Viral
%K Genetic Loci
%K Genome
%K Immune System
%K Immunoglobulin Variable Region
%K Immunoglobulin kappa-Chains
%K Mammary Tumor Virus, Mouse
%K Mice
%K Mice, Inbred C57BL
%K Molecular Sequence Annotation
%K Mutation
%K Open Reading Frames
%K Organ Specificity
%K Phylogeny
%K Protein Isoforms
%K Receptors, Antigen, T-Cell, alpha-beta
%K Superantigens
%U http://dx.doi.org/10.1186/1471-2172-12-5
%U http://www.ncbi.nlm.nih.gov/pubmed/21244697
%P 5

PT Journal
AU Lee, Y
   Chiu, S
   Chew, A
   Greenhalgh, DG
   Cho, K
TI Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.
SO BMC immunology
JI BMC Immunol.
PD 01
PY 2011
BP 5
VL 12
DI 10.1186/1471-2172-12-5
LA eng
DE Animals; Base Sequence; Chromosomes, Mammalian; DNA, Complementary; Female; Genes, Viral; Genetic Loci; Genome; Immune System; Immunoglobulin Variable Region; Immunoglobulin kappa-Chains; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred C57BL; Molecular Sequence Annotation; Mutation; Open Reading Frames; Organ Specificity; Phylogeny; Protein Isoforms; Receptors, Antigen, T-Cell, alpha-beta; Superantigens
AB Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V?-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.
ER

PMID- 21244697
OWN - NLM
STAT- MEDLINE
DA  - 20110215
DCOM- 20110715
LR  - 20150205
IS  - 1471-2172 (Electronic)
IS  - 1471-2172 (Linking)
VI  - 12
DP  - 2011
TI  - Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor 
      viruses in the genome of C57BL/6J mice and its potential implication in the
      immune system.
PG  - 5
LID - 10.1186/1471-2172-12-5 [doi]
AB  - BACKGROUND: Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a
      crucial role in T cell selection in the thymus in a T cell receptor (TCR)
      Vbeta-specific manner and SAgs presented by B cells activate T cells in the
      periphery. The peripheral T cell repertoire is dynamically shaped by the steady
      induction of T cell tolerance against self antigens throughout the lifespan. We
      hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to 
      the modulation of the peripheral T cell repertoire. RESULTS: SAg coding sequences
      were cloned from the genomic DNAs and/or cDNAs of various tissues of female
      C57BL/6J mice. A total of 68 unique SAg sequences (54 translated sequences) were 
      identified from the genomic DNAs of liver, lungs, and bone marrow, which are
      presumed to harbor only three endogenous MMTV loci (Mtv-8, Mtv-9, and Mtv-17).
      Similarly, 69 unique SAg sequences (58 translated sequences) were cloned from the
      cDNAs of 18 different tissues. Examination of putative TCR Vbeta specificity
      suggested that some of the SAg isoforms identified in this study have Vbeta
      specificities different from the reference SAgs of Mtv-8, Mtv-9, or Mtv-17.
      CONCLUSION: The pool of diverse SAg isoforms, generated by de novo somatic
      mutation, may play a role in the shaping of the peripheral T cell repertoire
      including the autoimmune T cell population.
FAU - Lee, Young-Kwan
AU  - Lee YK
AD  - Shriners Hospitals for Children Northern California and Department of Surgery,
      University of California-Davis, Sacramento, CA 95817, USA.
FAU - Chiu, Sophia
AU  - Chiu S
FAU - Chew, Alex
AU  - Chew A
FAU - Greenhalgh, David G
AU  - Greenhalgh DG
FAU - Cho, Kiho
AU  - Cho K
LA  - eng
GR  - R01 GM071360/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110118
PL  - England
TA  - BMC Immunol
JT  - BMC immunology
JID - 100966980
RN  - 0 (DNA, Complementary)
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Superantigens)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosomes, Mammalian/genetics
MH  - DNA, Complementary/genetics
MH  - Female
MH  - Genes, Viral/*genetics
MH  - Genetic Loci/genetics
MH  - Genome/*genetics
MH  - Immune System/*metabolism
MH  - Immunoglobulin Variable Region/genetics
MH  - Immunoglobulin kappa-Chains/genetics
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Annotation
MH  - Mutation/*genetics
MH  - Open Reading Frames/genetics
MH  - Organ Specificity/genetics
MH  - Phylogeny
MH  - Protein Isoforms/genetics
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics
MH  - Superantigens/*genetics
PMC - PMC3038982
OID - NLM: PMC3038982
EDAT- 2011/01/20 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/01/20 06:00
PHST- 2009/12/31 [received]
PHST- 2011/01/18 [accepted]
PHST- 2011/01/18 [aheadofprint]
AID - 1471-2172-12-5 [pii]
AID - 10.1186/1471-2172-12-5 [doi]
PST - epublish
SO  - BMC Immunol. 2011 Jan 18;12:5. doi: 10.1186/1471-2172-12-5.
TY  - JOUR
AU  - Lee, Young-Kwan
AU  - Chiu, Sophia
AU  - Chew, Alex
AU  - Greenhalgh, David G.
AU  - Cho, Kiho
PY  - 2011/01/18
TI  - Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.
T2  - BMC Immunol.
JO  - BMC immunology
SP  - 5
VL  - 12
KW  - Animals
KW  - Base Sequence
KW  - Chromosomes, Mammalian
KW  - DNA, Complementary
KW  - Female
KW  - Genes, Viral
KW  - Genetic Loci
KW  - Genome
KW  - Immune System
KW  - Immunoglobulin Variable Region
KW  - Immunoglobulin kappa-Chains
KW  - Mammary Tumor Virus, Mouse
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Molecular Sequence Annotation
KW  - Mutation
KW  - Open Reading Frames
KW  - Organ Specificity
KW  - Phylogeny
KW  - Protein Isoforms
KW  - Receptors, Antigen, T-Cell, alpha-beta
KW  - Superantigens
N2  - Superantigens (SAgs) of mouse mammary tumor viruses (MMTVs) play a crucial role in T cell selection in the thymus in a T cell receptor (TCR) V?-specific manner and SAgs presented by B cells activate T cells in the periphery. The peripheral T cell repertoire is dynamically shaped by the steady induction of T cell tolerance against self antigens throughout the lifespan. We hypothesize that de novo somatic mutation of endogenous MMTV SAgs contributes to the modulation of the peripheral T cell repertoire.
SN  - 1471-2172
UR  - http://dx.doi.org/10.1186/1471-2172-12-5
UR  - http://www.ncbi.nlm.nih.gov/pubmed/21244697
ID  - Lee2011
ER  - 
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